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    产品货号:NA-AH6-1
    促销: 9200.00
    价格: 9200.00

    分享

    250ug
    美国Indoor
    Allergen:
    nAra h 6 (Arachis hypogaea allergen 6)

    Unit:
    250µg

    Source:
    Light roasted peanut flour (Runner cultivar)

    Mol. Wt:
    14.5 kD

    Purification:

    From delipidated peanut extract by multi-step chromatography. Purity on silver stained SDS-PAGE >95%.

    Concentration:
    See Product Insert.

    Formulation:

    Preservative-free and carrier-free in phosphate buffered saline, pH 7.4. Sterile filtered.

    Storage:
    Store at -20ºC

    Notes:

    Trace Ara h 1 and Ara h 2 levels <0.05%.

    PDB:

    Allergens are provided for research and commercial use in vitro:  not for human in vivo or therapeutic use.

    References:


    1. Kleber-Janke T, Crameri R, Appenzeller U, Schlaak M, Becker WM. Selective cloning of peanut allergens, including profilin and 2S albumins, by phage display technology. Int Arch Allergy Immunol 1999; 119: 265-74.

    2. Suhr M, Wicklein D, Lepp U, Becker W. Isolation and characterization of natural Ara h 6: Evidence for a further peanut allergen with putative clinical relevance based on resistance to pepsin digestion and heat. Mol Nutr Food Res 2004; 48: 390-9.

    3. Koppelman S, de Jong G, Laaper-Ertmann M, Peeters K, Knulst A, Hefle S, Knol E. Purification and immunoglobulin E-binding properties of peanut allergen Ara h 6: evidence for cross-reactivity with Ara h 2. Clin Exp Allergy 2005; 35: 490-7.

    4. Peeters KA, Koppelman SJ, van Hoffen E, van der Tas CW, den Hartog Jager CF, Penninks AH, Hefle SL, Bruijnzeel-Koomen CA, Knol EF, Knulst AC. Does skin prick test reactivity to purified allergens correlate with clinical severity of peanut allergy? Clin Exp Allergy. 2007 Jan;37(1):108-15.

    5. Flinterman AE, van Hoffen E, den Hartog Jager CF, Koppelman S, Pasmans SG,Hoekstra MO, Bruijnzeel-Koomen CA, Knulst AC, Knol EF. Children with peanut allergy recognize predominantly Ara h2 and Ara h6, which remains stable over time. Clin Exp Allergy. 2007 Aug;37(8):1221-8.

    6. Porterfield HS, Murray KS, Schlichting DG, Chen X, Hansen KC, Duncan MW, Dreskin SC. Effector activity of peanut allergens: critical role for Ara h 2, Ara h 6, and their variants. Clin Exp Allergy 2009; 39: 1099-108.

    7. Blanc F, Adel-Patient K, Drumare M, E, Wal J, Bernard H. Capacity of purified peanut allergens to induce degranulation in a functional in vitro assay: Ara h 2 and Ara h 6 are the most efficient elicitors. Clin Exp Allergy 2009; 39: 1277-85.

    8. Flinterman AE, Pasmans S, den Hartog Jager CF, Hoekstra MO, Bruijnzeel-Koomen C, Knol EF, van Hoffen E. T cell responses to major peanut allergens in children with and without peanut allergy. Clin Exp Allergy 2010; 40: 590-7.